pentobarbital will decrease the extent or effect of parecoxib by affecting hepatic enzyme CYP2C9/10 metabolism. Use Warning/Watch.

pentobarbital will minimize the extent or influence of cilostazol by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor.

pentobarbital will minimize the extent or effect of lumefantrine by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Contraindicated. Coadministration with robust CYP3A4 inducers may result in lowered serum concentrations and lack of antimalarial efficacy

Phenytoin, sodium valproate, valproic acid: The result of barbiturates around the metabolism of phenytoin seems being variable. Some investigators report an accelerating impact, while others report no outcome. Since the impact of barbiturates over the metabolism of phenytoin isn't predictable, phenytoin and barbiturate blood amounts ought to be monitored much more regularly if these prescription drugs are supplied concurrently.

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Barbiturates have minor analgesic action at subanesthetic doses. Fairly, in subanesthetic doses these medications could boost the response to agonizing stimuli. All barbiturates exhibit anticonvulsant exercise in anesthetic doses.

fentanyl transdermal and pentobarbital both boost sedation. Avoid or Use Alternate Drug. Restrict use to patients for whom option treatment method alternatives are insufficient

pentobarbital will decrease the level or influence of rolapitant by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Steer clear of or Use Alternate Drug. Lengthy-term coadministration of sturdy CYP3A4 inducers with rolapitant could noticeably lessen rolapitant efficacy.

pentobarbital will minimize the extent or impact of mavacamten by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Contraindicated.

pentobarbital will reduce the level or effect of terbinafine by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Check.

pentobarbital will lessen the extent or outcome of capivasertib by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Steer clear of or Use Alternate Drug. Sturdy or reasonable CYP3A inducers minimize capivasertib exposure, which can lessen efficacy.

Even so, the serial serum pentobarbital concentrations and correlation with the get more info medical standing are noteworthy, Primarily enough time class to medical Restoration.

pentobarbital will lessen the level or effect of etravirine by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Check.

pentobarbital will lessen the level or result of cariprazine by influencing hepatic/intestinal enzyme CYP3A4 metabolism.